Lab's Focus
The overall objective of the Bristow laboratory is to gain a coherent understanding of how a cancer senses DNA double-strand breaks (dsbs) during its cell cycle. In particular, we are studying whether differences exist between normal and tumour cells in DNA break detection and repair. In this way, new cancer therapies can be discovered.
The lab is currently studying the interactions between the p53 tumour suppressor protein and a number of other DNA repair and damage sensing proteins during the various phases of the cell cycle. The molecular nature of DNA-dsb repair and cell cycle checkpoints can be determined using co-immunoprecipitation, immunofluorescent confocal microscopy and sub-nuclear microbeam irradation. The role of hypoxia in modifying DNA repair is also being studied.
- Dr. Robert Bristow's Bio
- Facilities
- Staff
- Areas of Research
- Funding Partners & Links
- Contact Us
This page was last updated October 6th, 2009 at 2:21pm.